While technology promises to connect us, it can also isolate; while mobility means our loved ones are only a train ride or flight away, we also move away from the communities where we grew up; while we increasingly have the opportunity to pursue our individual destinies, we can put our own goals ahead of our relationships and community; and despite all of the progress we have made in how we talk about mental health, we are still ashamed of feeling lonely. Dr. Murthy further contextualizes the subject with explorations of the social and evolutionary implications of our need to connect and what happens when we find ourselves untethered.